For the assessment of the effect of succinylcholine(SCh) on pancuronium, 62 adult patients undergoing elective surgery under general anesthesia were subjected to this study in which the EMG response(twitch hight) of the hand to TOF
stimulation(0.2
Hz)
of ulnar nerve was monitored and recorded with Datex Relaxograph.
According to the amount and mode of the drugs administered, the patients were divided into four experimental groups:
1) Group I, a bolus intravenous injection of pancuronium in dose of 0.05mg/kg.
2) Group Ⅱ, intravenous injection of pancuronium 0.1mg/kg, a double dose of group I.
3) Group Ⅲ, in travenous injection of pancuronium(0.05mg/kg)after 25 to 50% recovery of initial twitch height from twitch height depression induced by SCh(1mg/kg).
4) Group IV,mixed intravenous injection of SCh(1mg/kg)and pancuronium(0.05mg/kg).
@ES Followings were the results.
@EN 1) Mean onset time of the effect of pancuronium, was 15.6(1.1 minutes in group I and 13.8(1.5 minutes in group II, to 2.9(0.4 and 1.3(0.1 minutes in group III and IV respectively, and decreased(P<0.001).
2) Duration of action of pancuronfum was 47.1(4.5 minutes in group I and 87.7(7.4 minutes in group II, the prolongation of the latter being significant(P<0.001). It was, however 48.3(5.2 minutes in group III, indication that SCh showed a little
effect,
while it was 21.2(1.9 minutes in group IV, being significantly shorter than those of group I and III(P<0.001).
3) Potency of pancuronium expressed by the percentage changes of initial twich height was 34.3(6.0% in group I and it was noted to decrease significantly to 4.0(1.0% in group II and 0% in group IV(P<0.001), This pattern of decrease was almost
similar
to group II.
4) Presence of pancuronium(0.05mg/kg) in group IV did ont have any effect on the intensity of fasciculation induced by SCh.
These results indicate that succinylcholine could potentiate the onset time and acion potency of pancuronium by facilitating quick action on the receptor, but it have an antagonistic effect on the duration of action of pancuronium.
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